Naltrexone Bupropion SR weight loss medication
Naltrexone Bupropion SR weight loss medication

Naltrexone + Bupropion SR

Oral weight loss medication


Every 4 weeks

The same active ingredients as Contrave, which is FDA-approved for weight loss. It combines two medications (Naltrexone, and Bupropion SR) to work on separate areas of your brain to reduce hunger and control cravings. Clinical studies have shown it can be very effective for weight loss, however it isn’t as effective as injectable options.

  • Two pills taken twice daily
  • Alternative to injectable treatments
  • Lose 5–10% of your body weight a year
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Includes consultation & prescription

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Includes medication & shipping

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Includes clinical care & tracking

A graph comparing weight loss with medication plus diet and exercise, compared to weight loss with diet and exercise alone.

Lose up to 10% of your body weight a year

The combination treatment of Naltrexone and Bupropion SR has shown considerable effectiveness in supporting weight loss, with clinical studies indicating its potential for individuals to achieve a significant reduction of up to 10% of their body weight within a year. These studies have highlighted the impactful nature of this combination therapy in aiding weight management, particularly when complemented by lifestyle adjustments such as dietary modifications and increased physical activity.

How it works

Naltrexone + Bupropion SR, when used together for weight management, harnesses the properties of two medications to influence different aspects related to weight loss.

Naltrexone primarily works by affecting the reward system in the brain, reducing the desire for certain foods and potentially diminishing the feelings of pleasure associated with eating.

Bupropion SR, on the other hand, acts as an antidepressant and smoking cessation aid, but in this combination, its effect on weight loss is thought to be related to appetite suppression and potentially boosting metabolism.

Together, these medications appear to complement each other: Naltrexone helps curb cravings, while Bupropion SR may aid in reducing appetite and potentially increasing calorie expenditure. This combined approach aims to support individuals in managing their weight by influencing both food intake and the body's metabolic responses.

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Naltrexone + Bupropion SR FAQs

What is Naltrexone + Bupropion SR?

Jan 4, 2024

Naltrexone + Bupropion SR are two medications that make up the weight loss medication Contrave. This combination is used for weight management in adults with obesity or overweight people with weight-related health conditions. 

Naltrexone is mainly used to manage alcohol and opioid dependence and, in this combination, may help reduce food cravings. 

Bupropion SR is an antidepressant typically taken to help you stop smoking, but it may also help control appetite and potentially boost metabolism. 

Together, these medications aim to help you manage your weight by influencing food intake and metabolic responses.

How much weight can I expect to lose with Naltrexone + Bupropion SR?

Jan 4, 2024

Individual weight loss results with Naltrexone + Bupropion SR can vary widely. In clinical trials, people taking this combination medication for weight management experienced varying degrees of weight loss. On average, their weight loss ranged from approximately 5% to 10% of their initial body weight over the course of the trials, which typically lasted around 1–2 years.

Your weight loss can be influenced by various factors, including individual responses to the medication, consistency with treatment, lifestyle changes, metabolic differences and overall health. Some people might experience more significant weight loss, while others may see more moderate changes.

What are the potential side effects of Naltrexone + Bupropion SR?

Jan 12, 2024

Combining Naltrexone and Bupropion SR, this medication is similar to Contrave. During treatment it's important to be aware of potential side effects.

Common side effects of Naltrexone, Bupropion SR and Contrave:

Common side effects of Naltrexone + Bupropion SR and Contrave include nausea, headaches, dry mouth, constipation, sleep disturbances, increased heart rate, and potential mood changes or anxiety.

To manage nausea, individuals can try eating smaller, more frequent meals and staying hydrated. Insomnia can be addressed with good sleep hygiene practices. If these symptoms persist, consulting with a healthcare provider is recommended.

Other Naltrexone, Bupropion SR and Contrave side effects

While serious side effects are rare, individuals may experience increased blood pressure or heart rate. Monitoring these vital signs is important, and any concerning changes should be discussed with a healthcare professional.

Uncommon side effects, affecting 1 in 100 individuals, may include dizziness, anxiety, and gastrointestinal issues. If these symptoms persist or worsen, seeking medical advice is advisable.

Rare side effects (1 in 1,000) may involve liver-related concerns, such as hepatitis. If there are signs like jaundice or persistent abdominal pain, prompt medical attention is necessary.

Rare side effects might include seizures, especially during alcohol withdrawal. This is why it’s critical that you let the medical team know if you regularly consume large amounts of alcohol. It's important to discuss any concerns with your healthcare provider while using this medication.